Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia
Sung-Heon SONG; Young-Wook ROH; Yong-Woo AHN; Yeon-Jae KIM; Young-Sang BYOUN; Ji-Young CHOI; Deok-Won HWANG; Byoung-Bae PARK; Jung-Hye CHOI; In-Soon KIM; Byoung-Kook KIM; Young-Yiul LEE; Sung-Heon SONG; Young-Wook ROH; Yong-Woo AHN; Yeon-Jae KIM; Young-Sang BYOUN; Ji-Young CHOI; Deok-Won HWANG; Byoung-Bae PARK; Jung-Hye CHOI; In-Soon KIM; Byoung-Kook KIM; Young-Yiul LEE.
Korean Journal of Hematology
; : 100-103, 2009.
Artículo
en Ko
| WPRIM | ID: wpr-720044
The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid or lymphoid blast phase of CML. But for the case of the N-ras gene, the association between N-ras mutations and the blast phase of CML is not yet known. We report here on a case of detecting N-ras point mutation without p53 mutation in a 64 year-old man who suffered from the lymphoblastic blast phase of CML.
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WPRO
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