Lymphomas of
mucosa-associated
lymphoid tissue (MALT) comprise 7% of all newly diagnosed non-Hodgkin's
lymphomas.
Helicobacter pylori (H. pylori) negative gastric
MALT lymphomas account for 28 to 45% of gastric
MALT lymphomas. H. pylori
infection has a close relationship with most gastric low-grade B
cell lymphomas of the MALT type.
Monoclonal gammopathy can be seen in 36% of the
patients and negatively associated with responses to eradication of H. pylori in gastric
MALT lymphoma. Here, we describe a case of H. pylori negative
MALT lymphoma that arose from the
stomach with massive plasmacytic differentiation mimicking an extramedullary
plasmacytoma with
monoclonal gammopathy, and that was cured by total
gastrectomy,
chemotherapy and
radiotherapy.