The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice
Ho-Sun SONG; Tae-Wook PARK; Uy-Dong SOHN; Yong-Kyoo SHIN; Byung-Chul CHOI; Chang-Jong KIM; Sang-Soo SIM; Ho-Sun SONG; Tae-Wook PARK; Uy-Dong SOHN; Yong-Kyoo SHIN; Byung-Chul CHOI; Chang-Jong KIM; Sang-Soo SIM; Ho-Sun SONG; Tae-Wook PARK; Uy-Dong SOHN; Yong-Kyoo SHIN; Byung-Chul CHOI; Chang-Jong KIM; Sang-Soo SIM.
The Korean Journal of Physiology and Pharmacology
; : 343-347, 2008.
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| WPRIM | ID: wpr-728665
This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase A2 activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and PGE2 production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.
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