Adipsic
hypernatremia cause chronic hyperosmolality and
hypernatremia through a combination of impaired
thirst and osmotically stimulated
antidiuretic hormone secretion. This
syndrome can be grouped together as disorders of osmoreceptor dysfunction due to the various degrees of osmoreceptor destruction related with different types of intracranial lesions around the
anterior hypothalamus, consistent with the
location of primary osmoreceptor
cells. Adipsic
hypernatremia, associated with developmental disorder of
corpus callosum, is very rare. Most cases are diagnosed at infancy and early childhood; the replacement of
desmopressin is necessary. Herein, we
report adipsic
hypernatremia associated with anomalous
corpus callosum in
adult with
mental retardation; they were treated with only free
water without
desmopressin.