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Deep hypothermic circulatory arrest (DHCA) is an important assistant
technique for complex
cardiac surgery, which creates convenient operating conditions for
surgery, and is also one of the
measures to protect the
brain during operation. However, the
complications caused by this
technique cannot be ignored, and it should be noticed that the occurrence of intestinal
injury is relatively insidious, but brings great
pain to
patients and significantly reduces the
quality of life after operation. Studies have shown that intestinal
ischemia-reperfusion injury is induced by DHCA. It causes
mast cells to activate and release many inflammatory mediators that destroy the intestinal mucosal
epithelium barrier, and eventually
lead to intestinal
injury. This article reviewed the
research progress of
mast cells in the mechanism of DHCA-induced intestinal
injury.