Objective To investigate the relationship among
serum heat shock protein 70 (HSP70), suppressor of
Cytokine Signaling-3 ( SOCS-3) and
immune factor in
pregnant women with
hypertension ,and to analyze the diagnostic value of the two
indicators .
Methods Eighty-six
pregnant women with
hypertension who were treated in the Second People′s
Hospital of Yichang from January 2016 to February 2018 were selected,according to the severity of the
disease ,they were divided into
pre-eclampsia (51 cases) and severe
pre-eclampsia group (35 cases),another 40 normal
pregnant women in the same period were selected as
control group . The
serum levels of HSP70 and SOCS-3,
plasma immunoglobulin A (
IgA ),
immunoglobulin M (
IgM ),
immunoglobulin G (
IgG ),
complement C3 and
complement C4 levels were detected in each group,the correlation between
serum HSP70 and SOCS-3 levels and
immune factors were analyzed.
ROC curve was used to analyze the predictive value of
serum HSP70 and SOCS-3 in hypertensive disorder complicating
pregnancy . Results The
serum HSP70 of
pre eclampsia and severe
preeclampsia group was ( 3. 92 ± 0. 35 ) μg/L, the
serum HSP70 of
eclampsia group was ( 6. 45 ±0. 78) μg/L,which were significantly higher than that of the
control group ( 0. 36 ± 0. 07) μg/L, the differences were statistically significant (t=63. 272,49. 202,P<0. 05),the
serum SOCS-3 of
pre eclampsia and severe
preeclampsia group was (0. 22±0. 08) ng/L,the
serum SOCS-3 of
eclampsia group was (0. 10 ±0. 03) ng/L,which were significantly lower than ( 0. 62 ± 0. 11) ng/L that of the
control group ( 0. 62 ±0. 11) ng/L,the differences were statistically significant (t=-20. 078,-27. 079,P<0. 05),the
serum HSP70 of
eclampsia group was significantly higher than that of the
pre eclampsia and severe
preeclampsia group,the difference was statistically significant (t=-20. 402,P<0. 05),the
serum SOCS-3 of
eclampsia group was significantly lower than that of the
pre eclampsia and severe
preeclampsia group,the difference was statistically significant ( t=8. 462, P<0. 05) . The
plasma IgM was ( 1. 83 ± 0. 56) g/L,
IgG was ( 7. 94 ±1. 34) g/L,
complement C3 was (0. 95±0. 08) g/L,
complement C4 was (0. 24±0. 08) g/L in the
pre eclampsia and severe
preeclampsia group, the
plasma IgM was ( 1. 42 ± 0. 58 ) g/L,
IgG was ( 5. 23 ±1.13) g/L,
complement C3 was (0.73±0.12) g/L,
complement C4 was (0.13±0.05) g/L in the
eclampsia group,the
plasma IgM was (2. 55±0. 53) g/L,
IgG was (11. 04±2. 15) g/L,
complement C3 was (1. 28 ±0. 15) g/L,
complement C4 was (0. 35±0. 08) g/L in the
control group (
IgM t=-6. 232,-8. 815, P<0. 05;
IgG t=-8. 426,-14. 340, P<0. 05; C3 t=-13. 470,-17. 364, P<0. 05; C4 t=-6. 510,-14. 040,P<0. 05),the
plasma levels of
IgM ,
IgG ,
complement C3 and
complement C4 in
eclampsia group were significantly lower than those in
pre eclampsia and severe
preeclampsia group ( t=3. 288,-9. 805, 10. 209,7. 217,P<0. 05). Pearson correlation
analysis showed,there was a negative correlation among
serum HSP70 and
plasma IgM ,
IgG ,
complement C3 and
complement C4 in hypertensive
women with
gestational hypertension (r=-0. 446,-0. 537,-0. 426,-0. 428,P<0. 05),
serum SOCS-3 was positively correlated with
plasma IgM ,
IgG ,
complement C3 and
complement C4 (r=0. 423,0. 507,0. 416,0. 407,P<0. 05),there was no correlation among
serum HSP70, SOCS-3 and
plasma IgA in
pregnant women with
hypertension ( r=-0. 082,0. 093,P>0. 05). The area under the
ROC curve of HSP70 was 0. 821,and the critical value of the prediction was more than 0. 89 μg/L,the
sensitivity of HSP70 to
pregnant women with
hypertension was 86. 3%,the
specificity was 76. 4%,the area under the
ROC curve of SOCS-3 was 0. 759,the critical value of the prediction was less than 0. 035 ng/L,and the
sensitivity of SOCS-3 to
pregnant women with
hypertension was 79. 4%,and the
specificity was 71. 6%. Conclusion The abnormal increase of
serum HSP70 and abnormal decrease of SOCS-3 in
pregnant women with
hypertension , maternal
serum HSP70 and SOCS-3 levels are closely related to
immune factors ,the
serum HSP70 and SOCS-3 may be used as early predictors of hypertensive disorder complicating
pregnancy .