The clinical outcomes of five groups of
infertility patients receiving frozenthawed,cleavage-stage
embryo transfers with exogenous
hormone protocols with or without a depot
gonadotropin-releasing hormone (
GnRH ) agonist were assessed.A retrospective
cohort analysis was performed on 1003 cycles undergoing frozen-thawed,cleavage-stage
embryo transfers from January 1,2012 to June 31,2015 in the
Reproductive Medicine Center of Wuhan
General Hospital of Guangzhou
Military Region.Based on the
infertility etiologies of the
patients ,the 1003 cycles were divided into five groupstubal
infertility ,
polycystic ovary syndrome (PCOS),
endometriosis ,
male infertility ,and unexplained
infertility .The main outcome was the
live birth rate.Two groups were set up based on the interventiongroup A was given a
GnRH agonist with exogenous
estrogen and
progesterone ,and group B (
control group ) was given exogenous
estrogen and
progesterone only.The results showed that the baseline
serum hormone levels and basic characteristics of the
patients were not significantly different between groups A and B.The
live birth rates in groups A and B were 41.67% and 29.29%,respectively (P<0.05).The
live birth rates in
patients with PCOS in groups A and B were 56.25% and 30.61%,respectively (P<0.05).The clinical
pregnancy ,implantation and on-going
pregnancy rates showed the same
trends as the
live birth rates between groups A and B.The
ectopic pregnancy rate was significantly lower in group A than in group B.We concluded that the
live birth rate was higher and other clinical outcomes were more satisfactory with
GnRH agonist cotreatment than without
GnRH agonist co-
treatment for frozen-thawed
embryo transfer .The
GnRH agonist combined with exogenous
estrogen and
progesterone worked for all types of
infertility tested,especially for
women with PCOS.