Objective To launch systematic
research on long-term asymptomatic
hyperuricemia (HUA) from hemorheological
viewpoint,so as to provide references for clinical
treatment of asymptomatic HUA.
Methods Twenty
rats were randomly and evenly divided into normal
control group and model group.The
rats were intraperitoneally injected with 250 mg/(kg · d) oxonate for 8 weeks to induce the model of asymptomatic HUA.The
blood samples were obtained to
measure the
serum uric acid,hemorheological
parameters,oxidative and anti-oxidative indices.Results The aggregation index,
haemolysis rate,
serum xanthine oxidase (XOD),
plasma fibrinogen and
blood viscosity significantly increased,while the
orientation index,
electrophoresis rate,
serum superoxide dismutase (SOD),
activated partial thromboplastin time (APTT) and
prothrombin time (PT) significantly induced.Conclusions The asymptomatic HUA can
lead to more serious
oxidative stress,deteriorate the hemorheological
parameters of
red blood cells in
rats,and induce higher
blood viscosity and coagulation status.The
research findings indicate that asymptomatic HUA should be correctly understood and timely intervened in
clinical diagnosis.