Ligustrazine regulates LPS-induced apoptosis and inflammatory response of osteoarthritis chondrocytes via inhibiting phosphorylation of NF-κB P65 / 中国免疫学杂志
The LPS-induced abnormal cell morphology and decreased number of cells were ameliorated by ligustrazine ( 20 μmol/L). The apoptosis in LPS group was higher than control group ( P<0. 05). The LPS-induced enhancive apoptosis was reduced by ligustrazine ( P<0. 05). Compared with control group, the expression of collagenⅡ and aggrecan was alleviated with increased expression of MMP-13 ( P<0. 05). The LPS-induced declined expression of collagenⅡ and aggrecan and elevated expression of MMP-13 was inhibited by ligustrazine ( P<0. 05). The levels of NO, TNF-α and IL-6 in LPS group were higher than control group ( P<0. 05). The levels of NO, TNF-α and IL-6 in LPS+ligustrazine group were lower than LPS group ( P<0. 05). Compared with control group, the rate of pP65/P65 in LPPS group was enhanced ( P< 0. 05). The LPS-indiced increased rate of p-P65/P65 was decreased by ligustrazine ( P <0. 05).