Progress in the mechanism of glycometabolism in memory CD8+ T cell formation / 中华微生物学和免疫学杂志
Jingjing YAN; Mingbin LIU; Jianqing XU; Xiaoyan ZHANG.
Chinese Journal of Microbiology and Immunology
; (12): 145-149, 2019.
Artículo
en Zh
| WPRIM | ID: wpr-746061
CD8+T cells are critical immune cells protecting the body against infection and cancer. Long-lived memory CD8+T cells formed in a prior infection can reproduce to mount a faster and stronger im-mune response at a second encounter with the cognate antigen. The activation, clonal expansion and re-sponse of T cells are energetically demanding processes tightly coupled in cellular metabolism. Meanwhile, changes in cellular metabolism could also affect the development of memory T cells following acute infection. In this review, we discussed the current understanding of the mechanism by which glycometabolic pathways manipulate the differentiation of memory CD8+T cells in order to provide reference for improving vaccine de-velopment and cancer treatment.
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WPRO
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