OBJECTIVE@#To study the expressions of
matrix metalloproteinase-2 (
MMP-2) and
E-cadherin in laryngeal
carcinoma and their relationship with cervical
lymph node metastasis.@*
METHOD@#The expression of
MMP-2 and
E-cadherin in 10 cases of normal
laryngeal mucosa and 48 cases of supraglottic
carcinoma were detected by
immunohistochemistry.@*RESULT@#The expression of
MMP-2 in supraglottic
carcinoma was significantly higher than that in normal
laryngeal mucosa. The expression of
MMP-2 in metastatic
lymph nodes was significantly higher than that in nonmetastatic
lymph nodes (P < 0.05). The expression of
E-cadherin was significantly lower in supraglottic
carcinoma than that in normal
laryngeal mucosa. The expression of
E-cadherin was significantly lower in metastatic
lymph nodes than that in nonmetastatic
lymph nodes (P < 0.05). There is a negative correlation between the expression of
MMP-2 and
E-cadherin (r = -0.41). Predicting the
lymph node metastasis of laryngeal
carcinoma with the index of
MMP-2(+),
E-cadherin(-) and
MMP-2(+),
E-cadherin(-).
MMP-2(+) has the highest
sensitivity, but the lowest
specificity and
positive predictive value.
MMP-2(+),
E-cadherin(-) has the highest
specificity and
positive predictive value, but the lowest
sensitivity.@*CONCLUSION@#Expression of
MMP-2 and
E-cadherin can be used as a marker to predict
lymph node metastasis of supraglottic
carcinoma. Combined the
detection of
MMP-2 and
E-cadherin can boost the accuracy of prediction of
lymph node metastasis in supraglottic
carcinoma and provide efficient assistance for resecting supraglottic
carcinoma.