Influence of dual antiplatelet therapy combined different dose of atorvastatin calcium on serum levels of MCP‐1 and VE‐cadherin in patients with acute cerebral infarction/ / 心血管康复医学杂志
Compared with before treatment ,there was significant reduction in NIHSS score after 15d and 30d in two groups ,and those of 30d were significantly lower than those of 15d ,P=0. 001 all ;compared with routine dose group after 15d and 30d ,there was significant reduction in NIHSS score [15d(5.32 ± 1. 63 ) scores vs .(4. 13 ± 1.25 ) scores] in large dose group ,P= 0.001 ;Compared with routine dose group after 30d ,there were significant reduc‐tions in serum levels of hsCRP [(9.37 ± 1.85)mg/L vs.(6. 35 ± 1.94)mg/L] ,TNF‐α[(10. 15 ± 2.47)μg/L vs.(7. 44 ± 1.94)μg/L ] ,IL‐8 [(20. 35 ± 4.48 )μmol/L vs.(15. 14 ± 3. 61 ) μmol/L ] ,MCP‐1 [(234.54 ± 32. 53 ) ng/L vs. (185.46 ± 29. 47) ng/L] ,VE‐cadherin [(5. 32 ± 0. 49)mg/L vs.(4. 18 ± 0.54) mg/L] ,plaque size [(17.25 ± 3.14) mm2 vs.(14.13 ± 2.07)mm2 ] and IMT[(1.08 ± 0.25)mm vs.(0.85 ± 0. 17)mm] in large dose group ,P=0.001 all. There was no significant difference in incidence rate of adverse reaction between two groups .