Objective To investigate the relationship between
serum markers β
amyloid (Aβ), tau and
thyroid hormone levels and post-
stroke cognitive impairment (PSCI) in the acute phase of
cerebral infarction.
Methods A total of 214
patients with acute
cerebral infarction were enrolled. The baseline data and serological
indicators were collected and the
cognitive function of
patients was evaluated. All
patients were divided into
cognitive impairment group and normal group based on follow-up results. The differences of Aβ1-42,
tau protein and
thyroxine levels between the two groups and their relationship with
disease progression were analyzed. The Cox
regression analysis and
ROC curve were used to compare the above
parameters to predict the development of PSCI. Results The total
protein level of Tau (210.6 ±98.9 pg/mL) was higher and Aβ1-42 (426.1 ±123.5 pg/mL) and
triiodothyronine (T3) (1.43 ±0.57 nmol/L), free
thyroxine (FT4) (13.15±2.23 pmol/L) was significantly lower in the
cognitive impairment group than in the normal group (P<0.05).
Tau protein (r=-0.457), Aβ1-42 (r=0.348), T3 (r=0.211), and FT4 (r=0.306) were all associated with
disease progression (P<0.05). Cox
regression analysis showed that Aβ1-42 and T3 were important influencing factors in the occurrence of PSCI. The area under the curve of Aβ1-42 combined with T3 was 0.841. The
specificity and the
sensitivity were 74.8% and 85.3%, respectively, with a diagnostic cutoff value of 0.572. Conclusion Aβ1-42 and T3 levels in the acute phase of
cerebral infarction may predict the progression of PSCI.