Psoriasis is a chronic inflammatory
skin disease.Its pathogenesis remains unclear,and is currently considered to be co-mediated by
heredity,
environment and
immunity.
Signal transducer and activator of transcription 3 (STAT3) is an important
transcription factor,which is associated with
cancer and
autoimmune diseases.STAT3
plays a crucial
role in the occurrence of
psoriasis by participating in the differentiation of
T helper 17 cells,hyperproliferation and abnormal differentiation of
keratinocytes,interaction with inflammatory
cells,
hyperplasia of dermal vessels and other important
pathological processes.In recent studies,
therapies targeting STAT3 and its
upstream Janus kinases (JAK) have shown good
efficacy and
safety in the management of
psoriasis.This
review summarizes the
association between
psoriasis and STAT3,so as to provide evidence for the feasibility of the
treatment of
psoriasis with targeted inhibition of STAT3.