Acromegaly is a rare disorder caused by excessive amounts of
growth hormone. The
incidence of colorectal,
breast, and
thyroid carcinomas is increased in
acromegaly. However, there have been few
reports on
hematological malignancies in
acromegaly. We describe a
patient who developed
acute lymphoblastic leukemia during the
course of
acromegaly. A 35-year-old
woman presented in February 2012 with unexplained
lactation and
amenorrhea for 4 months. Her
growth hormone level was 12.6 microg/L,
insulin-like growth factor 1 592.26 ng/mL, and
prolactin 242 microg/L. A pituitary macroadenoma secreting GH and
prolactin causing
acromegaly was diagnosed. Considering her
fertility, the
dopamine agonist cabergoline 0.5 mg was administered in March 2012. In February 2014, she presented with
cytopenia (
hemoglobin 12.2 g/dL,
white cell count 2.69 x 10(9)/L,
platelets 39 x 10(9)/L) and hepatosplenomegaly. A
bone marrow examination showed acute B
cell lymphoblastic leukemia. She underwent
chemotherapy and
bone marrow transplantation. A follow-up
bone marrow biopsy showed remission.