Large Unstained Cell, Blast Suspect and Delta Neutrophil Index ll Analyzed with Automated Hematology Analyzer as Parameters for the Prediction of Acute Leukemia Relapse
Here we investigated the clinical utilities of blast suspect, large unstained cell (LUC), deltaneutrophil index ll (DN ll), and deltaneutrophil index l (DN l), analyzed in peripheral blood samples with automated hematology analyzers to predict the relapse of acute leukemia.
Significant differences in blast suspect (P<0.001), LUC (P<0.001), DN ll (P<0.001), and DN l (P=0.002) were observed between the leukemiarelapse and control groups. The areas under the curve (AUC) value was 0.927 for blast suspect (95% confidence interval [CI] 0.8750.978, P<0.001), 0.868 for LUC (95% CI 0.794–0.941, P<0.001), and 0.900 for DN ll (95% CI 0.841–0.960, P<0.001). Logistic regressionanalysis for the prediction of leukemiarelapse revealed odds ratio values of 1.52 (95% CI 1.26–1.96, P=0.0002) for blast suspect, 1.66 (95% CI 1.27–2.42, P=0.0019) for LUC, 1.16 (95% CI 1.08–1.29, P=0.0014) for DN ll, and 1.05 (95% CI 1.01–1.13, P=0.0845) for DN l.