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Metronidazole-Induced Encephalopathy with Thiamine Deficiency

Rae-Young KIM; Deok-Soo LEE; Byeong-Cheol GWAG; Yoon-Kyung LEE; Sang-Myeong CHEON; Jin-Heon JEONG.
Artículo en Ko | WPRIM | ID: wpr-766643
Metronidazole-induced encephalopathy (MIE) can be caused by excessive dose or prolonged metronidazole administration. The signal abnormalities in the cerebellar dentate nuclei, midbrain, dorsal pons and corpus callosum on magnetic resonance imaging are considered as the characteristic feature of MIE. Although the mechanism of MIE remains to be elucidated, various hypothesis have been proposed including the role of metronidazole as a thiamine antagonist. Here we report a 58-year-old woman with MIE who coincidentally presented with thiamine deficiency.
Biblioteca responsable: WPRO