Metronidazole-induced
encephalopathy (MIE) can be caused by excessive
dose or prolonged
metronidazole administration. The signal
abnormalities in the cerebellar dentate nuclei,
midbrain, dorsal
pons and
corpus callosum on
magnetic resonance imaging are considered as the characteristic feature of MIE. Although the mechanism of MIE remains to be elucidated, various hypothesis have been proposed including the
role of
metronidazole as a
thiamine antagonist. Here we
report a 58-year-old
woman with MIE
who coincidentally presented with
thiamine deficiency.