Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy / 神经科学通报·英文版
Xiaoling ZHANG; Bing SUN; Xing WANG; Hui LU; Fangjie SHAO; Annemieke-J-M ROZEMULLER; Huazheng LIANG; Chong LIU; Jiadong CHEN; Manli HUANG; Keqing ZHU.
Neuroscience Bulletin
; (6): 183-192, 2019.
Artículo
en Inglés
| WPRIM | ID: wpr-775460
Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study, we analyzed the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART, Alzheimer's disease (AD), and aging control cases. We examined the regional distribution patterns of pTDP-43 intraneuronal inclusions in PART with Braak NFT stages > 0 and ≤ IV, and a Thal phase of 0 (no beta-amyloid present). We found four stages which indicated potentially sequential dissemination of pTDP-43 in PART. Stage I was characterized by the presence of pTDP-43 lesions in the amygdala, stage II by such lesions in the hippocampus, stage III by spread of pTDP-43 to the neocortex, and stage IV by pTDP-43 lesions in the putamen, pallidum, and insular cortex. In general, the distribution pattern of pTDP-43 pathology in PART cases was similar to the early TDP-43 stages reported in AD, but tended to be more restricted to the limbic system. However, there were some differences in the distribution patterns of pTDP-43 between PART and AD, especially in the dentate gyrus of the hippocampus. Positive correlations were found in PART between the Braak NFT stage and the pTDP-43 stage and density.
Asunto(s)
Anciano Anciano de 80 o más Años Femenino Humanos Masculino Persona de Mediana Edad Envejecimiento Metabolismo Patología Encéfalo Metabolismo Patología Proteínas de Unión al ADN Metabolismo Progresión de la Enfermedad Inmunohistoquímica Cuerpos de Inclusión Patología Ovillos Neurofibrilares Metabolismo Patología Neuronas Metabolismo Patología Índice de Severidad de la Enfermedad Tauopatías Metabolismo Patología
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