The
incidence of
nonalcoholic fatty liver disease (
NAFLD) has been increasing in
China year by year, and
NAFLD has become the second most common
liver disease after viral
hepatitis. Its development is closely associated with
insulin resistance and
oxidative stress and
NAFLD is one of the important components of
metabolic syndrome.
Ghrelin is a newly discovered endogenous
ligand for
growth hormone secretagogue and has broad
biological functions.
Ghrelin not only
affects the
metabolic process of
glucose and
lipids, but also
plays an important
role in the development and progression of
NAFLD. In this
review, the
role of endogenous
Ghrelin expression in the development and progression of
NAFLD is briefly summarized and the
Ghrelin regulation in the development and progression of
NAFLD is pointed out, which
will provide new approaches to the clinical
treatment of
NAFLD.