Objective The aim of this study was to investigate
associations of overall
obesity (OO) and
abdominal obesity (AO) with brachial-
ankle pulse wave velocity (baPWV) among
type 2 diabetes(T2DM)
patients.
Methods A
community-based study for T2DM
patients was conducted in
rural communities in
Beijing.Every
patient completed a
questionnaire to collect
demography,
lifestyle and
diseases history, and underwent
physical examinations, baPWV assessments and
blood biochemical tests. Multivariate
linear regression was used to assess the relationship between
obesity index and baPWV. Abnormal baPWV was defined as
patients with baPWV≥1,700 cm/s.
Logistic regression model was performed to explore the
risk of abnormal baPWV after adjusting for poetential confounders step by step. Results A total of 2 048 T2DM
patients were recruited. The average age was (59.2±8.3) years and total
prevalence of abnormal baPWV was 49.7%. After multivariable
adjustment,
linear regression showed that there was a negative correlation between
body mass index(BMI) and baPWV and a positive correlation between
waist-to-hip ratio (WHR) and baPWV. Compared to normal weight group, those with BMI≥28 kg/m2 had lower
risk of abnormal baPWV (OR=0.59, 95% CI 0.44-0.78,P<0.001), but there was an increased
risk of 46% among
patients with
obesity in WHR (OR=1.46, 95% CI1.07-2.00,P=0.018). Compared to those without OO and AO,
patients without OO but with AO had a 1.67-fold increasesd
risk of abnormal baPWV (OR=1.67, 95% CI 1.19-2.35,P=0.003). Conclusions
Abdominal obesity is related with arterial stiffnening among T2DM
patients, and it is critical to evaluate
arterial stiffness of T2DM
patients with abdmonal
obesity and normal BMI in order to reduce
future risk of
cardiovascular diseases.