Objective This study combined genotyping with
family doctors' contracting model to assess the application of
precision medicine in rural
patients with
essential hypertension.
Methods In this study, 209 hypertensive
patients from 3 villages in Lujiang County, Hefei City, Anhui Province were selected as subjects and randomly divided into experimental group(n=105) and
control group(n=104). The medication regimen of
observation group was guided by
genetic testing for
gene sensitivity to
antihypertensive drugs, and the
control group was implemented routine
pharmacy. All the
patients were managed by
family doctors.
Adverse drug reaction rate,
treatment compliance,
blood pressure,
body mass index (BMI),
fasting blood glucose (FBG),
cholesterol (TC), and
triglycerides (TG) of the two groups were analyzed, respectively, during the 6-month intervention. Results After 6-month of intervention, the
medication compliance of the experimental group were significantly higher than that of the
control group, and the
blood pressure and
adverse drug reaction rate were significantly lower than that of the
control group. After 3 months of intervention, there was no significant decrease in BMI, FBG, TC and TG in the two groups. After 6 months of intervention, the FBG, TC and TG of the experimental group were significantly decreased,while only the FBG value of the
control group was significantly decreased. There were no significant changes in
body mass index (BMI) values in both groups. Conclusions Individualized medication guided by genotyping can improve the
treatment compliance, reduce the
adverse drug reaction rate, and improve the
treatment efficiency of
patients with
essential hypertension.