Highly oxygenous trichilin-type limonoids from Trichilia sinensis / 中国天然药物
Fa-Liang AN; Yong YIN; Jun LUO; Ling-Yi KONG; Fa-Liang AN; Yong YIN; Jun LUO; Ling-Yi KONG.
Chinese Journal of Natural Medicines (English Ed.)
; (6): 912-917, 2019.
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en Inglés
| WPRIM | ID: wpr-781238
Six new trichilin-type limonoids (1-6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including H NMR, C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L.
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