mass spectrometry have been developed and applied in clinics. However,
mass spectrometry has not been widely implemented yet relative to other measurement
methods, including biochemical assays,
immunoassays, and
molecular diagnostics. Despite its strong advantage as an analytical
method, many
laboratory physicians and
clinical laboratories are unwilling to introduce it. Fundamental
elements, such as instruments,
reagents, facilities, skilled
human resources are required to implement
mass spectrometry. This
review contains considerations for the introduction of
liquid chromatography-mass spectrometry to support the
clinical laboratories interested in or
planning to implement
mass spectrometry.