In eight rabbits, the calvarium was exposed and the two marrows were penetrated. After then these artificial bone defects were augmented with beta-TCP or beta-TCP with PRP or beta-TCP with PRF and covered. The animals were sacrificed after four and eight weeks. Histologic findings were observed under the light-microscope and histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD.
RESULTS:
They demonstrated that new bone formation tended to be produced along the outline of graft materials. More amounts of newly bone was regenerated in beta-TCP only and in combination ofbeta-TCP with PRF and it was statistically significant. In contrast, there was no significant difference between nothing apply and beta-TCP with PRP groups in the relative amounts of newly mineralized bone.
CONCLUSION:
Within the limitation of this study, it can be concluded that PRF in combination with beta-TCP showed a positive effect on bone regeneration and statistically it was significant.