Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times / 世界急诊医学杂志（英文）
Ming LIU; Hai-Rong WANG; Jia-Fu LIU; Hao-Jun LI; Shen-Xing CHEN; Sha SHEN; Shu-Ming PAN.
World Journal of Emergency Medicine
; (4): 205-209, 2013.
Artículo
en Zh
| WPRIM | ID: wpr-789622
BACKGROUND:
The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.METHODS:
A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.RESULTS:
National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).CONCLUSIONS:
The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.
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WPRO
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