Erzhiwan includes two components of
Chinese herbal medicines -
Ligustri Lucidi Fructus and Herba Eclip-tae .
Ligustri Lucidi Fructus ,Herba Ecliptae and their formulation have various hepatoprotective effects .There are many ac-tive ingredients in the formulation ,such as
triterpenes ,
iridoids ,
phenethyl alcohol-
glucosides ,coumarin
ethers ,etc .They can resist various
chemistry-induced hepatic
injury ,
ischemia reperfusion induced hepatic
injury ,and hepatic
fibrosis .The mecha-nisms of hepatoprotective effect include
anti-oxidative stress ,anti-inflammatory ,inhibition of
hyperplasia and activation of
liver stellate
cell ,motivating the
apoptosis of
liver stellate
cell ,influencing the
metabolic processes of
liver cell ,ect .We reviewed and summarized the hepatoprotective effects of Erzhiwan and its components
Ligustri Lucidi Fructus and Herba Ecliptae and explore the mechanisms of hepatoprotective effect in order to provide information for further
research of pharmacodynamic ma-terial base .