Objective: To observe the effect of addition and subtraction
therapy of Guyinjian on
oocyte quality,
pregnancy outcome and
ovarian reserve function in
patients with poor ovarian response (POR) with
kidney Yin deficiency syndrome .
Method: Ninety
patients were randomly divided into
control group (45 cases) and
observation group (45 cases) by random number table. The
patients in both groups got antagonist. Based on such
treatment , the
patients in
observation received additional addition and subtraction
therapy of Guyinjian. The using
time and amount of
gonadotropin (Gn),
ovum taking cycle, cycle canceling rate,
fertilization rate, available
embryo rate, quality
embryo rate,
ovulation cycle clinical
pregnancy rate were recorded. Levels of
follicle stimulating hormone (FSH),
luteinizing hormone (LH),
serum estradiol (E2) and endometrial thickness,
anti mullerian hormone (AMH), resistance index (RI), pulsation index (PI), end diastolic velocity (EDV) and peak systolic velocity (PSV) were detected. Ratio of PSV/EDV (S/D) was calculated, and scores of
kidney yin deficiency syndrome were graded before and
after treatment .
Result: Total amount of Gn in
observation group was less than that in
control group (PP2 were higher than those in
control group (PPPχ2=5.124, Pχ2=5.767, PPPPP
Conclusion: Addition and subtraction
therapy of Guyinjian can increase ovarian
blood supply , improve high
ovarian reserve function, reduce Gn
consumption , increase number of acquired
eggs , alleviate symptoms of
kidney yin deficiency , and can ameliorate ovarian responsiveness and
pregnancy outcome .