Salivary glands mucosa-associated lymphoid tissue lymphoma (SGML) is a distinct subtype of marginal zone B-
cell type non-Hodgkin′s
lymphoma (NHL), which is commonly seen in
middle aged females. SGML is usually associated with
autoimmune diseases such as Sjögren's
syndrome or with
chronic infection such as
hepatitis C virus (HCV)
infection.
Chromosomal abnormalities are frequently seen in SGML, which usually activate nuclear factor-κB molecular pathway to modulate
cell survival and proliferation, resulting in
lymphoma occurrence. SGML tends to arise from
parotid gland, presenting frequently as a localized and indolent lesion, a long-term follow-up and
biopsy are needed for accurate
diagnosis.
Surgery,
radiotherapy and
chemotherapy are usually effective disseminated
diseases at multiple sites need combined
treatment. SGML has a relatively better
prognosis with a higher
relapse rate than other types of NHLs, dissemination or higher degree of malignant transformation may occur. Thus, a long-term and close follow-up is essential for
patients with SGML.