Objective@#To investigate the causes of
disease among
patients with
liver disease hospitalized in Department of
Infectious Diseases in our
hospital and the changes in such causes within the past 20 years.@*
Methods @#A retrospective
analysis was performed for the clinical data of 7570
patients who were admitted to our
hospital from January 1995 to December 2015. The
chi-square test was used for the
statistical analysis of constituent ratio.@*Results@#Of all 7570
patients with
liver disease , 4930 (65.13%) had viral
hepatitis , 332 (4.39%) had
immune disease , 215 (2.84%) had drug-induced liver injury, 192 (2.54%) had
fatty liver disease , 88 (1.16%) had schistosome-induced
liver disease , 160 (2.11%) had inherited
metabolic diseases , and 20 (0.13%) had
vascular disease ; 689 (9.1%) still had no clear cause of
disease at discharge. The proportion of
patients with viral
hepatitis was 77.61% in the first 10 years and 59.19% in the last 10 years (P < 0.01). As for
liver disease caused by hepatotropic
virus , there were significant increases in the proportion of
patients with
hepatitis C or
hepatitis E from the first to the last 10 years (
hepatitis C 2.24% vs 15.56%, P < 0.01;
hepatitis E 18.61% vs 23.07%, P < 0.05), while there were significant reductions in the proportion of
patients with
hepatitis B (68.14% vs 60.01%, P < 0.05) or
hepatitis A (10.7% vs 1.36%, P < 0.05). The proportion of
patients with
immune diseases was 0.82% in the first 10 years and 6.08% in the last 10 years (P < 0.01). There were also certain changes in the proportion of
patients with
liver disease caused by other reasons.@*Conclusion@#There is a large proportion of
patients with viral
hepatitis among
patients with
liver disease hospitalized in Department of
Infectious Diseases in a large
general hospital , especially
hepatitis B and E caused by hepatotropic
virus . There is a certain change in the
epidemiology of
liver disease within the past 20 years, with a reduction in the proportion of
patients with viral
hepatitis and an increase in the proportion of
patients with non-infectious
liver diseases . There is a large proportion of
patients with unknown causes of
liver disease .