Objective@#To observe the changes of peripheral
blood image of
chronic hepatitis C (CHC)
patients treated with pegylated
interferon (Peg-IFN) and
ribavirin , and explore the relationship between the changes and
serum virological respose (SVR).@*
Methods @#
Patients with CHC treated with Peg-IFN α-2 a and
ribavirin in the Second Division of
Liver Disease in
Beijing Ditan
Hospital were monitored for peripheral
blood cells routine examination and
Liver function,
kidney function,
thyroid function at baseline and week 2, 4, 8, 12, 24, 36, 48, and week 12, 24, 48 after the end of
treatment for
chronic hepatitis C , and HCV
RNA .@*Results@#The decrease of peripheral
blood cell counts began to appear at week 2 of
treatment . For CHC
patients without
cirrhosis ,
white blood cells ,
lymphocyte ,
hemoglobin and
platelets at week 2, while minimum values were seen at week 36, and the
neutrophils reached the minimum value to at week 24. Significant recovery of the peripheral
blood changes was seen at the end of
treatment (48 weeks), and reached pre-
treatment levels at week 48 after the end of
treatment . For CHC
patients with
cirrhosis ,
white blood cells ,
lymphocytes ,
hemoglobin and
platelets significantly decreased at week 2, while
neutrophils reached a minimum value at 2 weeks. And
hemoglobin and
platelets reached a minimum value at 24 weeks, and the
white blood cells reached the minimum value at weeks 24-36 besides
lymphocyte reached the minimum value at week 36. Significant recovery was seen at the end of
treatment (48 weeks), and the
blood cell counts reached pre-
treatment levels at 48 weeks after the end of
treatment . For
patients with CHC,
hemoglobin decreased by more than 27.47% at week 4, which means that the
patient would have a predictive significance for SVR, as well as the of PLT reduction by more than 36.96% at week 8.@*Conclusions@#During the
treatment with Peg-
interferon and
ribavirin , the variation of
blood picture has some predicting effect, which predicts the result of
antiviral treatment .