Objective@#To summarize the clinical features of 7 rare cases of
hemolytic disease of newborn (HDN), and to improve the
understanding of rare HDN.@*
Methods@#Data of clinical information,
laboratory findings,
treatments and outcomes were collected and analyzed for four cases with HDN due to anti-M, two cases due to anti-Kidd, and one case due to anti-Duffy. All of them were admitted to the Department of
Neonatology,
Beijing Children's
Hospital Affiliated to
Capital Medial
University from July 2007 to June 2017.@*Results@#Among the four MN hemolytic babies, two were
males and two were
females.
Jaundice was found in three cases. Two cases had
hyperbilirubinemia, one of them had severe
hyperbilirubinemia. All the four cases developed
anemia, including severe
anemia in three cases. Two cases of Kidd hemolytic
disease and 1 case of Duffy hemolytic
disease had
jaundice and
anemia, but did not reach the level of severe
hyperbilirubinemia and severe
anemia. MN hemolytic
disease babies got
negative results in
direct antiglobulin test, whereas the Kidd and Duffy hemolytic
disease babies had positive findings in
direct antiglobulin test. None of the babies had
blood transfusion, and they were discharged from the
hospital.@*Conclusions@#Without maternal and
fetal blood group incompatibility (ABO or Rh
blood-group system), for early onset of
jaundice, severe
jaundice or
anemia,
antiglobulin test to
mother and
child earlier should be administered, and MN, Kidd, Duffy and other rare hemolytic
disease of the
newborn should be pay
attention to.