Tripolinolate A (TLA) is recently identified as a new compound from a
halophyte plant Tripolium vulgare and has been shown to have significant
in vitro activity against the proliferation of
colorectal cancer and
glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of
human normal
cells, and the
apoptosis and
cell cycle in
colorectal cancer cells, and the
growth of
tumors in the
colorectal cancer-bearing
animals. The data obtained from this study demonstrated that 1) TLA had much less cytotoxicity in the
human normal
cells than the
colorectal cancer cells; 2) TLA remarkably induced
apoptosis in the
human colorectal cancer cells and blocked
cell cycle at G/
M phase, and 3) TLA had significant anti-
colorectal cancer activity in the
tumor-bearing
animals.