The detection rate of depression and anxiety in patients with chronic wounds was 45.3% and 14% respectively. In patients with chronic wounds, age was positively correlated with SDS and SAS scores (P<0.05), while education, eight factors of SF-36, objective support, subjective support, and social support scores of SSRS were negatively correlated with SDS and SAS scores (P<0.05). Further multiple regression analysis showed that the duration of wounds, physical functional score, role physical score and role emotional score of SF-36, objective support score, subjective support score, support utilization score, and social support score of SSRS were the independent influential factors for SDS score (P<0.05). Education, general health score, social functional score, and mental health score of SSRS were the independent factors for SAS score (P<0.05).