DJ-1 gene rearrangement mutation in patients with autosomal recessive early-onset parkinsonism using real-time PCR

Hainan ZHANG; Bin XIAO; Liluo NIE; Jifeng GUO; Chunyu WANG; Lei WANG; Dan HE; Xinxiang YAN; Beisha TANG

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DJ-1 gene rearrangement mutation in patients with autosomal recessive early-onset parkinsonism using real-time PCR / 中南大学学报(医学版)

Hainan ZHANG; Bin XIAO; Liluo NIE; Jifeng GUO; Chunyu WANG; Lei WANG; Dan HE; Xinxiang YAN; Beisha TANG.

Journal of Central South University(Medical Sciences) ; (12): 438-444, 2010.

Artículo en Zh | WPRIM | ID: wpr-814432

OBJECTIVE@#To establish a technique platform of DJ-1 gene exon rearrangement using real-time PCR and to analyze DJ-1 gene exon rearrangement mutation in patients with autosomal recessive early-onset Parkinsonism(AREP).@*METHODS@#Real-time PCR was used to analyze DJ-1 gene exon rearrangement mutation in 22 probands with AREP from unrelated Chinese Han families and 30 normal controls.@*RESULTS@#We obtained satisfactory real-time PCR reaction conditions and primers of DJ-1 gene coding exons No exon rearrangement mutation in the DJ-1 gene is detected in this group.@*CONCLUSION@#We established platform of DJ-1 gene exon rearrangement using real-time PCR. Exon rearrangement mutation in the DJ-1 gene is rare in Chinese patients with AREP.

Asunto(s)

Adolescente Adulto Niño Preescolar Femenino Humanos Masculino Adulto Joven Edad de Inicio China Etnología Análisis Mutacional de ADN Exones Genética Reordenamiento Génico Péptidos y Proteínas de Señalización Intracelular Genética Mutación Proteínas Oncogénicas Genética Trastornos Parkinsonianos Genética Proteína Desglicasa DJ-1 Reacción en Cadena de la Polimerasa de Transcriptasa Inversa

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DJ-1 gene rearrangement mutation in patients with autosomal recessive early-onset parkinsonism using real-time PCR / 中南大学学报(医学版)

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