OBJECTIVE: To systematically evaluate the difference of
therapeutic efficacy of Xianling gubao
capsules combined with routine
therapy for
postmenopausal osteoporosis (PMOP).
METHODS: Retrieved from Cochrane
Library,
PubMed, Embase, ClinicalTrials, CNKI, VIP, Wanfang database and CBM, clinical randomized controlled trials (RCTs) about Xianling gubao
capsules combined with placebo and routine
treatment (trial group) versus placebo and routine
treatment or Xianling gubao
capsules (
control group) alone in the
treatment of PMOP were collected. After
literature screening and data extraction, the quality of included
literatures were evaluated with Cochrane system evaluator manual 5.3 recommend
bias risk evaluation tool. Bayesian
Network Meta-analysis was performed with Stata 14.0
software and Bayesian
Markov Chain Monte Carlo. RESULTS: A total of 16 RCTs were included, involving a total of 1 360
patients and 3 intervention
measures as Xianling gubao
capsules alone, Xianling gubao
capsules combined with routine
treatment, routine
treatment. Results of
Meta-analysis showed that in
respect of improving total response rate, compared with routine
treatment, Xianling gubao
capsules combined with routine
treatment [OR=0.28,95%CI(0.12, 0.64),P<0.05]could significantly improve total response rate;
network Meta-analysis ranking showed that Xianling gubao
capsules combined with routine
treatment>Xianling gubao
capsules alone>routine
treatment. In terms of increasing
bone mineral density (BMD), compared with routine
treatment, Xianling gubao
capsules combined with routine
treatment [OR=0.45,95%CI(0.24, 0.84),P<0.05] and Xianling gubao
capsules alone [OR=0.78, 95%CI(0.32, 0.84),P<0.05] could significantly improve BMD;
network Meta-analysis ranking showed that Xianling gubao
capsules combined with routine
treatment>Xianling gubao
capsules alone>routine
treatment. In the term of improving
serum calcium level, compared with Xianling gubao
capsules alone [OR=4.76,95%CI(2.14, 10.59),P<0.05] and routine
treatment [OR=0.45, 95%CI(0.21, 0.99),P<0.05], Xianling gubao
capsules combined with routine
treatment could significantly improve
serum calcium level;
network Meta-analysis ranking showed that Xianling gubao
capsules combined with routine
treatment>routine
treatment>Xianling gubao
capsules alone. In the term of improving
serum phosphorus level, compared with Xianling gubao
capsules alone, Xianling gubao
capsules combined with routine
treatment [OR=2.85,95%CI(1.81, 4.48),P<0.05] and routine
treatment [OR=2.93,95%CI(1.76, 4.86),P<0.05] could significantly improve
serum phosphorus level;
network Meta-analysis ranking showed that routine
treatment>Xianling gubao
capsules combined with routine
treatment>Xianling gubao
capsules alone. CONCLUSIONS: Xianling gubao
capsules combined with routine
treatment can significantly improve
therapeutic efficacy of PP
patients, increase BMD and
serum calcium level
after treatment, but routine
treatment is the best in improving
serum phosphorous level.