OBJECTIVE@#To investigate the effects of Xinjikang on the
left ventricular hypertrophy remodeling and myocardial activity in
hypertension.@*
METHODS@#Sixty
Wistar rats were randomly divided into four groups. The
pressure-loaded
left ventricular hypertrophy model was established with
abdominal aorta ligation method.
Rats in A and B groups were intragastrically administered with physiological saline, while C and D groups were administered with Xinjikang and
metoprolol, respectively. The changes in
blood pressure, E/A ratio, myocardial pathological morphology, myocardial
lipoperoxides and
superoxide dismustase activity in four groups were observed and compared before and
after treatment.@*RESULTS@#There were statistically significant differences in E/A ratio between C group
after treatment and model group (P0.05);
after treatment the myocardial
lipoperoxides and
superoxide dismustase contents in C and D groups were improved significantly compared with model group (P<0.05).@*CONCLUSIONS@#Xinjikang can improve myocardial
injury, restore myocardial parenchyma and myocardial interstitial
remodeling functions in hypertensive
rats with the
left ventricular hypertrophy.