Free radical scavenging potential of Lagenaria siceraria (Molina) Standl fruits extract
Vijayakumar MAYAKRISHNAN; Selvi VELUSWAMY; Krishnakumari-Shanmuga SUNDARAM; Priya KANNAPPAN; Noorlidah ABDULLAH.
Asian Pacific Journal of Tropical Medicine
; (12): 20-26, 2013.
Artículo
en Inglés
| WPRIM | ID: wpr-820573
OBJECTIVE@#To elucidate free radical scavenging activity of ethanolic extract Lagenaria siceraria (L. siceraria) (Molina) fruit.@*METHODS@#The free radical scavenging activity of the L. siceraria (Molina) fruit extract was assayed by using α,α-diphenyl-β-picrylhydrazyl (DPPH), 2,20-azinobis 3-ethyl benzothiazoline-6-sulfonate (ABTS), FRAP, reducing power, chelating ability and β-carotene bleaching assay.@*RESULTS@#The IC(50) values of DPPH and ABTS radical-scavenging activity was found to be 1.95 mg/mL and 19 mg/mL, respectively. In ferrous chelation assay, the percentage of inhibition was found to be 89.21%. The reducing power of ethanolic extract of L. siceraria (Molina) fruit was 0.068 at 1 mg/mL and increased to 0.192 at 5 mg/mL. The β-carotene linoleate bleaching assay was 46.7% at 5 mg/mL and antioxidant activity using FRAP at 0.305 for 1 mg/mL to 0.969 for 5 mg/mL.@*CONCLUSIONS@#The results indicate that L. siceraria (Molina) fruit could be an important sources of natural radical scavengers.
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