Objective @# To investigate the clinical use of glassceramiconlay in the restoration of the non-vital posterior teeth with computer aided design and computer-aided manufacturingtechnique (CAD/CAM). @*Methods @# 70 patients with 75 teeth of residual crown were selected and restored with CAD/CAM glass-ceramiconlay after completely root canal therapy. Marginal adaptation, anatomic form, adjacent relation, contour appearance, color match were checked in 12-month follow-up. @*Results @# Marginal adaptation, anatomic form, adjacent relation, contour appearance, color match of 73 teeth were satisfactory and 2 cases was excluded because of lost to follow-up. There were no significant differences in the number of cases which met clinical criterion A or B between immediate restoration and 12-month follow-up (P > 0.05), and more than 95% of cases met clinical criterion A.@*Conclusion @#The CAD/CAM glass-ceramiconlay in the restoration of non-vital posterior teeth can provide better effect of retention and esthetics in a short term observation of 12 months.