Objective To investigate
chromosome abnormality rate and related factors of
spontaneous abortion in early
pregnancy.
Methods A total of 831
tissue samples of
spontaneous abortion in early
pregnancy were collected from June 2015 to August 2018 in the First Affiliated
Hospital of Nanjing Medical
University. Chromosomal copy number was analyzed by
next generation sequencing (NGS). The relationships between
chromosome abnormality and
maternal age,
in vitro fertilization?
embryo transfer (IVF?ET)
pregnancy, number of previous
spontaneous abortions,
history of
live birth were analyzed by statistical
methods. Results Among 831
tissue samples of
spontaneous abortion in early
pregnancy, 461 (55.5%, 461/831) were found to have
chromosome abnormalities.
Maternal age (OR=1.107, 95%CI 1.070-1.145) and
history of
live birth ( OR=1.909, 95%CI 1.182-3.083) were the positive correlative factors of
chromosome abnormality. Times of previous
spontaneous abortion (OR=0.807, 95%CI 0.702-0.928) and IVF?ET
pregnancy ( OR=0.554, 95%CI 0.404-0.760) were the negative correlative factors of
chromosome abnormality. Conclusions
Chromosome abnormality is an important cause of
spontaneous abortion in early
pregnancy. The rate of
chromosome abnormality increases with the increase of
maternal age and the
history of
live birth, and decreases with the increase of number of previous
spontaneous abortion and IVF?ET
pregnancy.