OBJECTIVE@#To assess the
association of
apolipoprotein (apo) C1 (APOC1)
gene rs4420638A/G and -317H1/H2 polymorphisms with the
risk of
pre-eclampsia (PE) and the influence of their
genotypes on the clinical and metabolic indexes among
Chinese women.@*
METHODS@#In total 289 PE
patients and 824
women with uncomplicated
pregnancies were included. The rs4420638A/G
genotype was determined by a Taqman
real-time PCR allelic discrimination assay. The -317H1/H2
genotype was measured through
PCR and
restriction fragment length polymorphism analysis.
Serum lipid and apo levels were measured by an enzymatic kit and a PEG-enhanced
immunoturbidimetric assay.@*RESULTS@#Allelic and genotypic frequencies of the APOC1
gene rs4420638A/G and -317H1/H2 were not significantly different between the two groups (all P> 0.05). However,
patients carrying the G
allele of the rs4420638A/G locus had higher
serum levels of
triglyceride, non-HDL-C and
apoB, and a higher
apoB/apoA1 ratio compared with those with an AA
genotype (all P< 0.05).
Patients carrying the H2
allele of the -317H1/H2 polymorphism had smaller delivery gestational weeks compared with those with the H1H1
genotype (P< 0.05).@*CONCLUSION@#Polymorphisms of the APOC1
gene rs4420638 and -317H1/H2 sites may be associated with abnormal
lipoprotein metabolism among
Chinese patients with PE, though no
association was found between variants of the APOC1
gene and the
risk of PE among them.