BACKGROUND@#New
treatment methods such as targeted
therapy and
immune checkpoint inhibitors have been applied to
lung cancer patients. It is necessary to further understand the
patients with
lung cancer combined with
pulmonary tuberculosis with the development of
lung cancer research. The purpose of this study was to analyze the clinical characteristics of
lung cancer patients with
pulmonary tuberculosis, the status of driver
genes, and their relationships.@*
METHODS@#A retrospective
analysis was performed on 405
patients with
lung cancer and
pulmonary tuberculosis hospitalized in our
hospital from January 2014 to December 2019. The relationship between clinical characteristics and driver
genes status was analyzed.@*RESULTS@#Among the 405
patients with
lung cancer combined with
pulmonary tuberculosis, 77.3% were
male and 85.3% were
patients with a
history of
smoking. The pathological type was mainly
lung adenocarcinoma. When there were cavities in
chest computed
tomography (CT) ,
squamous cell carcinoma was the main type. 214
patients underwent driver
genes testing. The
epidermal growth factor receptor (EGFR)
gene mutation rate was 35.9%, of which 41.8% were
exon 19
deletion mutations and 50.9% were
exon 21 L858R
mutations. When there were cavities in the
chest CT, the EGFR
mutation rate was significantly reduced (16.1%). The positive rate of
anaplastic lymphoma kinase (ALK) fusion
gene detection was 2.5%, the
mutation rate of c-ros
oncogene 1 receptor
kinase (ROS1)
gene was 1.9%, the
mutation rate of V-raf murine
sarcoma viral
oncogene homolog B1 (BRAF)
gene was 1.1%, and the
mutation rate of Kirsten
Rat Sarcoma Viral
Oncogene Homolog (KRAS)
gene was 10.1%. The genetic
mutation rate of
female patients with
lung cancer and
pulmonary tuberculosis was 50.0%, and that of
men was 27.9%.@*CONCLUSIONS@#
Patients with
lung cancer and
pulmonary tuberculosis are predominantly
male with
smoking history.
Adenocarcinoma is the most common pathological type. The positive rate of
gene mutation was not significantly different from that of simple
lung cancer, but when there were cavities in the
chest image, the genetic
mutation rate was significantly reduced.