Gliomas are malignant
tumors with strong invasiveness. The current
treatment strategy is surgical
treatment assisted by a variety of
radiotherapies,
chemotherapies and
immunotherapies. However, the curative
efficacy is limited.
Adrenergic receptor (AR) is an important stress
hormone receptor, which is highly involved in the
regulation of the
tumorigenesis and progression of various
tumors by activating different
downstream signal transduction pathways. Recent studies have shown that AR is dysregulated in
glioma cells and
tissues, and
plays an important
role in a series of
biological behaviors such as
tumorigenesis, invasion and
metastasis of
glioma. This article reviews the
research progress of AR in the field of
glioma in recent years, which provides a theoretical basis for the prevention and
treatment of
glioma targeting the AR.