High-quality data are the foundation to monitor the progress and evaluate the effects of road trafficinjury prevention measures. Unfortunately, official road trafficinjurystatistics delivered by governments worldwide, are often believed somewhat unreliable and invalid. We summarized the reported problems concerning the road trafficinjurystatistics through systematically searching and reviewing the literature. The problems include absence of regular data, under-reporting, low specificity, distorted cause spectrum of road trafficinjury, inconsistency, inaccessibility, and delay of data release. We also explored the mechanisms behind the problematic data and proposed the solutions to the addressed challenges for road trafficstatistics.