OBJECTIVE@#To study the influencing factors for the clinical effect of
bronchoalveolar lavage (BAL) in
children with
Mycoplasma pneumoniae pneumonia (MPP) and
atelectasis.@*
METHODS@#A total of 75
children with MPP and
atelectasis were divided into a good response group with 51
children and a poor response group with 24
children according to the clinical effect of BAL
treatment. LASSO
logistic regression analysis was used to investigate the factors influencing the clinical effect of BAL
treatment. The
receiver operating characteristic (ROC) curve and restricted cubic spline model
analysis were used to evaluate the value of the
course of the
disease at the
time of BAL
treatment in predicting the clinical effect of BAL
treatment.@*RESULTS@#Compared with the good response group, the poor response group had a significantly lower percentage of
lymphocytes in
bronchoalveolar lavage fluid, a significantly higher proportion of
children with
atelectasis of two or more
lung lobes or
stenosis of the bronchial cavity or opening caused by
inflammation, and a significantly longer
course of the
disease at the
time of BAL
treatment and
azithromycin treatment (P<0.05). The LASSO
logistic regression analysis showed that a prolonged
course of the
disease at the
time of BAL
treatment (OR=1.23),
atelectasis of two or more
lung lobes (OR=11.99), and
stenosis of the bronchial cavity or opening caused by
inflammation (OR=5.31) were independent
risk factors for poor clinical effect of BAL
treatment (P<0.05). The
ROC curve analysis showed that the
course of
disease of ≥11.5 days at the
time of BAL
treatment suggested a poor clinical effect of BAL
treatment, with a
sensitivity of 91.7% and a
specificity of 54.9%. The restricted cubic spline model
analysis showed that there was a non-linear
dose-response relationship between the
course of
disease at the
time of BAL
treatment and the clinical effect of BAL
treatment (P<0.05).@*CONCLUSIONS@#Early BAL
treatment may have a good clinical effect in
children with MPP and
atelectasis.
Atelectasis of two or more
lung lobes and
inflammation-induced
stenosis of the bronchial cavity or opening shown under
bronchoscope may indicate a poor clinical effect of BAL
treatment.