Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects
Yan CHEN; Chen CHEN; Xiaojuan ZHANG; Chuanchuan HE; Pengxuan ZHAO; Minsi LI; Ting FAN; Ruicong YAN; Yao LU; Robert-J LEE; Muhammad-Waseem KHAN; Muhammad SARFRAZ; Xiang MA; Tan YANG; Guangya XIANG.
Acta Pharmaceutica Sinica B
; (6): 1106-1121, 2020.
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| WPRIM | ID: wpr-828820
Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both and . In addition, Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.
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