OBJECTIVE@#To investigate the effect of
dexmedetomidine combined with pulmonary protective
ventilation against
lung injury in
patients undergoing surgeries for
esophageal cancer with
one-lung ventilation (OLV).@*
METHODS @#Forty
patients with undergoing
surgery for
esophageal cancer with OLV were randomly divided into pulmonary protective
ventilation strategy group (F group) and
dexmedetomidine combined with protective
ventilation strategy group (DF group; =20). In F group,
lung protective
ventilation strategy during
anesthesia was adopte, and in DF group, the
patients received
intravenous infusion of
dexmedetomidine hydrochloride (0.3 μg · kg ·h) during the
surgery starting
at 10 min before
anesthesia induction in addition to protective
ventilation strategy.
Brachial artery blood was sampled before
ventilation (T), at 30 and 90 min after the start of OLV (T and T, respectively) and at the end of the
surgery (T) for
analysis of
superoxide dismutase (SOD),
malondialdehyde (MDA),
tumor necrosis factor -α (TNF-α),
interleukin-6 (
IL-6 ), arterial
oxygenation pressure (PaO),
oxygenation index (OI) and
lung compliance (CL).@*RESULTS@#At the
time points of T, T and T, SOD level was significantly higher and
IL-6 level was significantly lower in the DF group than in F group ( < 0.05). The
patients in DF group showed significantly higher PaO, OI and CL index than those in F group at all the 3
time points.@*CONCLUSIONS@#
Dexmedetomidine combined with pulmonary protective
ventilation strategy can reduce perioperative
lung injury in
patients undergoing
surgery for
esophageal cancer with OLV by suppressing
inflammation and
oxidative stress to improve
lung function and reduce
adverse effects of the
surgery .