Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson’s Disease
Jin-cheol SEO; Jin-young WON; Keon-woo KIM; Jung-hyung PARK; Hyeon-Gu YEO; Yu-Gyeong KIM; Seung-Ho BAEK; Hoonwon LEE; Chang-Yeop JEON; Won-Seok CHOI; Sangil LEE; Ki-Jin KIM; Sung-Hyun PARK; Yeong-hoon SON; Kang-Jin JEONG; Kyung-Seob LIM; Philyong KANG; Hwal-Yong LEE; Hee-Chang SON; Jae-Won HUH; Young-Hyun KIM; Dong-Seok LEE; Sang-Rae LEE; Ji-Woong CHOI; Young-jeon LEE.
Experimental Neurobiology
; : 376-388, 2020.
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| WPRIM | ID: wpr-832464
ymptoms of Parkinson’s disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.
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