Background@#
Reports of metastatic
sarcoma to the
pancreas are limited. We reviewed the clinicopathologic characteristics of such cases. @*
Methods@#We reviewed 124 cases of metastatic
tumors to the
pancreas diagnosed at Asan Medical Center between 2000 and 2017. @*Results@#Metastatic
tumors to the
pancreas consisted of 111
carcinomas (89.5%), 12
sarcomas (9.6%), and one
melanoma (0.8%). Primary
sarcoma sites were
bone (n = 4);
brain,
lung, and soft
tissue (n = 2 for each); and the
uterus and
pulmonary vein (n = 1 for each). Pathologically, the 12
sarcomas comprised 2
World Health Organization grade III
solitary fibrous tumors/
hemangiopericytomas, and one case each of
synovial sarcoma, malignant
solitary fibrous tumor, undifferentiated pleomorphic
sarcoma,
osteosarcoma,
mesenchymal chondrosarcoma, intimal
sarcoma, myxofibrosarcoma,
myxoid liposarcoma,
rhabdomyosarcoma, subtype uncertain, and high-grade spindle-
cell sarcoma of uncertain type. The median interval between primary
cancer diagnosis and pancreatic
metastasis was 28.5 months. One case manifested as a solitary pancreatic
osteosarcoma metastasis 15 months prior to
detection of
osteosarcoma in the
femur and was initially misdiagnosed as sarcomatoid
carcinoma of the
pancreas. @*Conclusions@#The metastatic
sarcoma should remain a
differential diagnosis when spindle-
cell malignancy is found in the
pancreas, even for solitary lesions or in
patients without prior
history.