Stable MHD patients of Ruijin Hospital, Shanghai Jiao Tong UniversitySchool of Medicine were enrolled in July 2012. These patients were followed for 1 year. Clinical characteristics and laboratory indices were collected at baseline and 1-year followup. Left ventricular mass (LVM) was evaluated by ultrasonic cardiogram. Left ventricular mass index (LVMI) increased more than 5% was defined as LVH progression.
Results:
Totally 71 MHD patients were enrolled in this study. 44 patients were males, with median age 55.9 years old, median dialysis vintage 152.1 months. 22 (30.99%) patients had LVH at enrollment. A significant higher percentage of MHD patients used calcium-channel binder (CCB) and angiotensin-converting-enzyme inhibitor (ACEI) in LVH group, while a significant higher NT-proBNP level was also showed in LVH group. 31 patients had LVH progression while 40 patients didn't after 1 year. Patients in progression group had significant higher levels of total cholesterol and lowdensity lipoproteincholesterol (LDL-C). In univariable and multivariable Logistic regression, total cholesterol and LDL-C were independent risk factors of LVH progression (OR=2.515, 95% CI 1.219-5.910, P=0.013; OR=1.950, 95% CI 1.127-3.375, P=0.017).