The mechanism and research progress of obeticholic acid in the intervention of non-alcoholic fatty liver disease / 国际药学研究杂志
Liang-Yong JIANG.
Journal of International Pharmaceutical Research
; (6): 423-426, 2019.
Artículo
en Zh
| WPRIM | ID: wpr-845285
Non-alcoholic fatty liver disease(NAFLD)is a relatively common chronic liver disease with imbal- anced lipid metabolism, and its incidence is increasing year by year. NAFLD is closely related to bile acid excretion, ab- normal bile acid synthesis and liver fibrosis. Farnesolid X receptor(FXR)regulates bile acid transport, inhibits bile acid synthesis and resists liver fibrosis. Obeticholic acid is a targeted drug for the treatment of NAFLD targeting the farnesol X receptor, which can effectively regulate fat metabolism and blood sugar balance. This review summarizes the mechanism and research progress of obeticholic acid intervention in NAFLD, and provides a theoretical basis for its foundamental re- search and clinical application.
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